beta-2-Thienyl-L-alanine → HCID 45256706, compound

Reaction equation

Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][C@@H:17]([CH2:21][C:22]1[S:23][CH:24]=[CH:25][CH:26]=1)[C:18]([OH:20])=[O:19]>>[C:18]([C@@H:17]([NH:16][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:21][C:22]1[S:23][CH:24]=[CH:25][CH:26]=1)([OH:20])=[O:19]

Participants

Reactant 2

HCID 146719beta-2-Thienyl-L-alanine

HCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 45256706HCID 45256706, compound

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with (S)-2-amino-3-thiophen-2-yl-propionic acid to provide the title compound in good yield.

Sources & evidence

ORD record: ord-a7d6f405b16c4da1b27297b7065d3d81
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288549B2

Reaction notes

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