HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Bromoethyl)cyclohexane → 8-(2-Cyclohexylethoxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Bromoethyl)cyclohexane | HCID 15440 | — |
| Reactant | 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one | HCID 24849570 | — |
| Product | 8-(2-Cyclohexylethoxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one | HCID 24849712 | — |
Reaction Steps
The title compound was prepared from (2-bromoethyl)cyclohexane and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedure outlined in Example 25. 1H NMR (400 MHz, DMSO-d6): δ 9.52 (s, 1H), 8.82 (s, 2H), 7.95 (d, 1H), 7.21 (d, 1H), 4.64 (s, 1H), 4.02 (t, 2H), 3.92 (s, 3H), 1.80-1.50 (m, 8H), 1.70 (m, 3H), 0.90 (m, 2H); MS (ESI): 463.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745646B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-c5c15509ded04e4699aa5fafff3fe60b |
| Source note | uspto-grants-2010_06 |