HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 8-(5-Aminopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 8-(5-Bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one | HCID 24849569 | — |
| Product | 8-(5-Aminopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one | HCID 24849886 | — |
Reaction Steps
The title compound was prepared from 28% NH4OH solution and 8-(5-bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one (Example 28) following the procedure outlined in Example 52. 1H NMR (400 MHz, DMSO-d6; HCl salt): δ 9.64 (s, 1H), 8.81 (s, 2H), 8.00 (d, 1H), 7.83 (br, 3H), 7.21 (d, 1H), 4.63 (s, 1H), 3.98 (t, 2H), 3.92 (s, 3H), 2.79 (m, 2H), 1.75-1.50 (m, 6H); MS (ESI): 437.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745646B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-92ede4a64a14441ab8ac910e5ee5345c |
| Source note | uspto-grants-2010_06 |