3-Ethyl-4-hydroxy-5-methylbenzonitrile → HCID 178436629, compound

HRID 2069412

Reaction equation

HRID 2069412 reaction equation
[CH3:1][C:2]1([CH3:21])[O:6][CH:5]([CH2:7][O:8][C:9]2[C:18]([CH3:19])=[CH:17][C:12]([C:13]([NH:15][OH:16])=[NH:14])=[CH:11][C:10]=2[CH3:20])[CH2:4][O:3]1.[CH2:22](C1C=C(C=C(C)C=1O)C#N)C>>[CH3:1][C:2]1([CH3:21])[O:6][C@@H:5]([CH2:7][O:8][C:9]2[C:10]([CH3:20])=[CH:11][C:12]([C:13]([NH:15][OH:16])=[NH:14])=[CH:17][C:18]=2[CH2:19][CH3:22])[CH2:4][O:3]1

Participants

3

Reactant 2

HCID 597599503-Ethyl-4-hydroxy-5-methylbenzonitrileHCID 178426655HCID 178426655, compound

Product 1

HCID 178436629HCID 178436629, compound

Procedure

The title compound is obtained as a yellow oil (0.77 g) in analogy to rac-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-N-hydroxy-3,5-dimethyl-benzamidine starting from 3-ethyl-4-hydroxy-5-methyl-benzonitrile and D-alpha-beta-isopropyliden glycerol; LC-MS: tR=0.68 min, [M+H]+=308.99.

Sources & evidence

ORD record
ord-13c5db27542845d2966bcdc7a70472d7
Source dataset
uspto-grants-2012_10
Patent number
US08299086B2

Linked notes

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