Dichloromethane → Valine methyl ester
Reaction equation
Cl.[NH2:2][C@H:3]([C:7]([OH:9])=[O:8])[CH:4]([CH3:6])[CH3:5].Cl[CH2:11]Cl>>[CH3:11][O:8][C:7](=[O:9])[C@H:3]([CH:4]([CH3:6])[CH3:5])[NH2:2]Participants
3
Procedure
500 mg of methyl ester of L-(+)-valine hydrochloride are placed in a round-bottom flask. 45 mL of buffer solution (K2HPO4/K3PO4 (pH=12.4)), then 22.5 mL of anhydrous dichloromethane are successively added. The mixture is agitated at room temperature for 30 min. The organic phase is separated, washed with brine, dried on magnesium sulfate, filtered and concentrated under vacuum.
Workup
- customThe organic phase is separated
- washwashed with brine
- customdried on magnesium sulfate
- filtrationfiltered
- concentrationconcentrated under vacuum
Sources & evidence
- ORD record
- ord-21885dc629d74c55b99e3a5e8f9ffdb8
- Source dataset
- uspto-grants-2012_10
- Patent number
- US08299250B2
Reaction notes
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