(2-Methyl-5-nitrophenyl)pyrrolidine → 4-Methyl-3-(pyrrolidin-1-yl)aniline
Reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>CO.[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
The mixture containing (2-methyl-5-nitrophenyl)pyrrolidine in methanol with catalytic amount of 10% Pd/C was hydrogenated to yield 4-methyl-3-pyrrolidinylphenylamine.
Sources & evidence
- ORD record
- ord-a5e800b91c0644ab91b8f80f4d3cf579
- Source dataset
- uspto-grants-2012_10
- Patent number
- US08299108B2
Reaction notes
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