HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylpropylamine → 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(5-(methyl(propyl)amino)pentyloxy)-2H-chromen-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylpropylamine | HCID 12315 | — |
| Reactant | 8-(5-Bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one | HCID 24849569 | — |
| Product | 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(5-(methyl(propyl)amino)pentyloxy)-2H-chromen-2-one | HCID 24849299 | — |
Reaction Steps
The title compound was prepared from N-methylpropan-1-amine and 8-(5-bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one (Example 28) following the procedure outlined in Example 52. 1H NMR (400 MHz, DMSO-d6): δ 9.42 (br s, 1H), 8.58 (s, 2H), 7.86 (d, 1H), 7.06 (d, 1H), 4.24 (br s, 1H), 3.97 (t, 2H), 3.87 (s, 3H), 2.75-2.40 (br, 4H), 2.38 (br s, 3H), 1.70 (m, 2H), 1.60 (m, 2H), 1.49 (m, 4H), 0.83 (t, 3H); MS (ESI): 494.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745646B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-c84b386fd16d4385b865570a1cd0e83c |
| Source note | uspto-grants-2010_06 |