2-Fluoro-5-isopropylnicotinonitrile → (E)-5-(3-methylbut-1-enyl)nicotinonitrile

Reaction equation

Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6](/[CH:8]=[CH:9]/[CH:10]([CH3:12])[CH3:11])[CH:7]=1.FC1N=CC(C(C)C)=CC=1[C:16]#[N:17]>>[CH3:11][CH:10]([CH3:12])/[CH:9]=[CH:8]/[C:6]1[CH:5]=[N:4][CH:3]=[C:2]([CH:7]=1)[C:16]#[N:17]

Participants

Reactant 2

HCID 686699662-Fluoro-5-isopropylnicotinonitrile

HCID 68670697(E)-3-bromo-5-(3-methylbut-1-enyl)pyridine

Product 1

HCID 68671370(E)-5-(3-methylbut-1-enyl)nicotinonitrile

Procedure

(E)-5-(3-methylbut-1-enyl)nicotinonitrile was synthesized from (E)-3-bromo-5-(3-methylbut-1-enyl)pyridine following the general procedure as described for the 2-fluoro-5-isopropylnicotinonitrile.

Sources & evidence

ORD record: ord-92989807002744169bed36babdac718b
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08299267B2

Reaction notes

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