Thionyl Chloride → HCID 54066303, compound

HRID 2072625

Reaction equation

HRID 2072625 reaction equation
[CH2:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)[CH2:2][CH3:3].O=S(Cl)Cl.[CH2:17]([C:22]1[CH:27]=[CH:26][C:25]([C:28]2[N:29]=[CH:30][C:31](O)=[N:32][CH:33]=2)=[CH:24][CH:23]=1)[CH2:18][CH2:19][CH2:20][CH3:21]>N1C=CC=CC=1>[CH2:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([O:10][C:31]2[CH:30]=[N:29][C:28]([C:25]3[CH:26]=[CH:27][C:22]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[CH:23][CH:24]=3)=[CH:33][N:32]=2)=[O:9])=[CH:6][CH:5]=1)[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 24386Thionyl ChlorideHCID 1376014-Propylbenzoic acidHCID 178442096HCID 178442096, compound

Product 1

HCID 54066303HCID 54066303, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

16.4 g of 4-propyl benzoic acid are boiled for hour with 24 g of SOCl2, which is followed by evaporating, dissolving the acid chloride obtained in 150 ml of toluene, adding 8 ml of pyridine and 24.2 g of 5-(4-pentylphenyl)-2-pyrazinol (obtainable analogously to Japanese Preliminary Published Application 144,770/84) and boiling for 2 hours. Cooling down and customary working up gives 5-(4-pentylphenyl)-pyrazin-2-yl 4-propylbenzoate.

Workup

  1. customby evaporating
  2. dissolutiondissolving the acid chloride
  3. customobtained in 150 ml of toluene
  4. temperatureCooling down and

Sources & evidence

ORD record
ord-9f373bf39bcb4d09ae94cc71ce4973d7
Source dataset
uspto-grants-1990_04
Patent number
US04913837

Linked notes

Loading…