Acetic Anhydride → HCID 53739244, compound

HRID 2072840

Reaction equation

[Cl:1][C:2]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:3]=1[C:4]([CH2:6][C:7]#[N:8])=[O:5].[C:14]([O:17][C:18](=O)C)(=O)C>>[Cl:1][C:2]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:3]=1[C:4]([C:6](=[CH:14][O:17][CH3:18])[C:7]#[N:8])=[O:5]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 136307283-(2,4-Dichlorophenyl)-3-oxopropanenitrile

Product 1

HCID 53739244HCID 53739244, compoundYield 104.5%

Conditions

Temperature: 150 °C

Procedure

A mixture of 8.8 g of 2,4-dichloro-benzoylacetonitrile, 69.2 g of methyl o-formate and 10.5 g of acetic anhydride is refluxed at a bath temperature of 150° C. for 3 hours. The volatile constituents are then distilled off in vacuo and finally under a fine vacuum at a bath temperature of 120° C. 11 g of 2-(2,4-dichloro-benzoyl)-3-methoxy-acrylonitrile are obtained as a viscous oil.

Workup

distillationThe volatile constituents are then distilled off in vacuo and finally under a fine vacuum at a bath temperature of 120° C

Sources & evidence

ORD record: ord-391df9ca579547fd8fe272604eefc0dd
Source dataset: uspto-grants-1990_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04914228

Linked notes

Loading…