Pyridine → 1-bromo-2,5,8-tetradecatriyne
Reaction equation
O[CH2:2][C:3]#[C:4][CH2:5][C:6]#[C:7][CH2:8][C:9]#[C:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].N1C=CC=CC=1.P(Br)(Br)[Br:23]>C(OCC)C>[Br:23][CH2:2][C:3]#[C:4][CH2:5][C:6]#[C:7][CH2:8][C:9]#[C:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
6 g of 1-hydroxy-2,5,8-tetradecatriyne prepared above, dissolved in 30 cm3 of ethyl ether, are introduced into a round-bottomed flask equipped with an argon inlet. 0.05 cm3 of pyridine is added and 1 cm3 of phosphorus tribromide is added dropwise, and the mixture is then brought to reflux for 3 hours.
Workup
- additionare introduced into a round-bottomed flask
- customequipped with an argon inlet
- temperatureto reflux for 3 hours
Sources & evidence
- ORD record
- ord-f624ad7e6c1a4227a69570bad227941f
- Source dataset
- uspto-grants-1990_04
- Patent number
- US04916136
Reaction notes
Loading…