Ethyl 2-(morpholin-3-yl)acetate → HCID 66968183, compound
Reaction equation
[CH2:1]([O:3][C:4](=[O:12])[CH2:5][CH:6]1[CH2:11][O:10][CH2:9][CH2:8][NH:7]1)[CH3:2].[F:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[S:24][C:23]([CH3:25])=[N:22][C:21]=2[C:26](O)=[O:27])=[CH:16][CH:15]=1>>[CH2:1]([O:3][C:4](=[O:12])[CH2:5][CH:6]1[CH2:11][O:10][CH2:9][CH2:8][N:7]1[C:26]([C:21]1[N:22]=[C:23]([CH3:25])[S:24][C:20]=1[C:17]1[CH:18]=[CH:19][C:14]([F:13])=[CH:15][CH:16]=1)=[O:27])[CH3:2]Participants
3
Procedure
The title compound (1.48 g, 66%) was prepared from (RS)-morpholin-3-yl-acetic acid ethyl ester, D43 (1.37 g, 5.8 mmol) and 5-(4-fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid (1.00 g, 5.8 mmol) according to a procedure similar to that described for D16.
Sources & evidence
- ORD record
- ord-f9ca7297dcb04705a5ecb5f95dd7e5cf
- Source dataset
- uspto-grants-2011_04