4-(4-fluorophenyl)-1-methyl-1H-pyrazole-3-carboxylic acid → 4(4-Fluoro-phenyl)-1-methyl-1H-pyrazole-3-yl(2-furo[3,2-b]pyridin-2-ylmethyl-piperidin-1-yl)methanone
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([C:14]([OH:16])=O)=[N:10][N:11]([CH3:13])[CH:12]=2)=[CH:4][CH:3]=1.[NH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]1[CH2:23][C:24]1[O:32][C:31]2[C:26](=[N:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]([C:14]([N:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]3[CH2:23][C:24]3[O:32][C:31]4[C:26](=[N:27][CH:28]=[CH:29][CH:30]=4)[CH:25]=3)=[O:16])=[N:10][N:11]([CH3:13])[CH:12]=2)=[CH:6][CH:7]=1Participants
3
Procedure
The title compound was prepared using the method of Example 4, from 4-(4-fluoro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid (110 mg, 0.5 mmol) and (RS)-2-Piperidin-2-ylmethyl-furo[3,2-b]pyridine, D47 (108 mg, 0.5 mmol), as a colourless solid (130 mg, 62%).
Sources & evidence
- ORD record
- ord-3ddaadf29fdd4231a0e3b4801d2d5ad9