3-(2-Methylpropenyl)-benzylamine → 3-Isobutylbenzylamine

HRID 2080137

Reaction equation

HRID 2080137 reaction equation
[CH3:1][C:2]([CH3:12])=[CH:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][NH2:8]>C(O)C.[C].[Pd]>[CH2:3]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][NH2:8])[CH:2]([CH3:12])[CH3:1]

Participants

4

Reactant 1

HCID 231307203-(2-Methylpropenyl)-benzylamine

Product 1

HCID 231305533-IsobutylbenzylamineYield 56.6%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

3-(2-Methylpropenyl)-benzylamine described in Preparation Example 137 (100 mg, 0.621 mmol) was dissolved in ethanol (5 mL), 10% palladium-carbon (50% water wet, 20 mg) was added thereto, and the mixture was stirred for 2 hours at room temperature under hydrogen atmosphere. The catalyst was filtered, then, the solvent was evaporated, and the title compound (58 mg, 56.6%) was obtained as a colorless oil.

Workup

  1. filtrationThe catalyst was filtered
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-f49fab2946984f2d92c5d12888688d44
Source dataset
uspto-grants-2011_04
Patent number
US07932272B2

Linked notes

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