Ammonium Chloride → HCID 19780253, compound
Reaction equation
[CH2:1]([C:8]1[N:13]=[C:12]([C:14](=[NH:17])OC)[CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-:18].[NH4+:19]>C(O)C>[ClH:18].[CH2:1]([C:8]1[N:13]=[C:12]([C:14]([NH2:17])=[NH:19])[CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of methyl 6-benzyl-2-picoline imidate (0.81 g, 0.0036 moles) and ammonium chloride (0.21 g, 0.0039 moles) in ethanol (9 ml) was refluxed for 5 hours. The ethanol was removed in vacuo to give 6-benzyl-2-picoline amidine hydrochloride which was used in the final stage without further purification.
Workup
- temperaturewas refluxed for 5 hours
- customThe ethanol was removed in vacuo
Sources & evidence
- ORD record
- ord-cbbe57ffb2994fe0adf991e5ff8a72d5
- Source dataset
- uspto-grants-1993_02
- Patent number
- US05185339
Reaction notes
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