Trifluoroacetic anhydride → Acetic acid, trifluoro-, (methylnitroamino)methyl ester

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Reaction Steps

Trifluoroacetic anhydride (80 ml, 118.4 g, 0.56 moles) was added to a stirred solution of 1-hydroxy-2-nitro-2-azapropane (40.0 g, 0.38 moles) in dichloromethane (60 ml) at -5° to 0° C. during 11/2 hours. The resulting solution was then distilled without warming at 20 mm, then to 3 mm. The product was distilled at 1.5 mm, 65° C., to give 2-nitro-2-azapropyl trifluoroacetate; yield: 48 g (63%).

Provenance & Evidence