4-tert-Butylbenzylamine → Tebufenpyrad

HRID 2082050

Reaction equation

HRID 2082050 reaction equation
[CH2:1]([NH:3][C:4]([C:6]1[N:10]([CH3:11])[N:9]=[C:8]([CH2:12][CH3:13])[C:7]=1[Cl:14])=[O:5])[CH3:2].[C:15]([C:19]1[CH:26]=[CH:25]C(CN)=[CH:21][CH:20]=1)([CH3:18])([CH3:17])[CH3:16]>>[C:15]([C:19]1[CH:26]=[CH:25][C:2]([CH2:1][NH:3][C:4]([C:6]2[N:10]([CH3:11])[N:9]=[C:8]([CH2:12][CH3:13])[C:7]=2[Cl:14])=[O:5])=[CH:21][CH:20]=1)([CH3:18])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 27356554-tert-ButylbenzylamineHCID 54498586Ethyl 4-chloro-3-ethyl-1-methylpyrazole-5-carboxamide

Product 1

HCID 86354Tebufenpyrad

Conditions

Temperature
200 °C

Procedure

A mixture of ethyl 4-chloro-3-ethyl-1-methylpyrazole-5-carboxamide and 4-tert-butylbenzylamine is heated to 200° C. for four hours with continuous stirring. Thereafter the reaction mixture is cooled to room temperature and the reaction mixture purified by silica gel chromatography to obtain the desired product 115°-117° C.

Workup

  1. temperatureThereafter the reaction mixture is cooled to room temperature
  2. customthe reaction mixture purified by silica gel chromatography

Sources & evidence

ORD record
ord-644c9dc91c47401fa1b452f761d7dbde
Source dataset
uspto-grants-1993_02
Patent number
US05187184

Linked notes

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