HCID 12535827, compound → HCID 12535828, compound

Reaction equation

[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[C:12]([N+:14]([O-])=O)[CH:11]=[CH:10][C:9]=2[O:17][CH2:18][CH3:19])=[N:5][CH:4]=[C:3]1[C:20]([O:22][CH2:23][CH3:24])=[O:21].[H][H]>[Pd].C(O)C>[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[C:12]([NH2:14])[CH:11]=[CH:10][C:9]=2[O:17][CH2:18][CH3:19])=[N:5][CH:4]=[C:3]1[C:20]([O:22][CH2:23][CH3:24])=[O:21]

Participants

Procedure

A mixture of ethyl 1,6-dihydro-6-oxo-2-(2-ethoxy-5- nitrophenyl)pyrimidine-5-carboxylate (0.42 g., 1.26 mmoles) and 10% palladium on carbon (0.07 g.) in ethanol (200 ml.) was treated with hydrogen at a pressure of about 3.5 kg./cm2 until uptake of hydrogen ceased. The mixture was filtered and the filtrate reduced to dryness. The residue was recrystallized from water followed by aqueous ethanol to give the title compound (0.12 g., 31.6%), m.p. 107°-110°.