N-bromobutanimide → Ethyl 2-(bromomethyl)-4-fluorobenzoate
Reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][CH:3]=1.[Br:14]N1C(=O)CCC1=O>>[Br:14][CH2:8][C:6]1[C:5]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][CH:3]=[C:2]([F:1])[CH:7]=1Participants
3
Procedure
Reaction of ethyl 5-fluoro-o-toluate with N-bromosuccinimide as described in Example 1a provides ethyl α-bromo-5-fluoro-o-toluate as an oil.
Sources & evidence
- ORD record
- ord-1c3e8c02a01e497e86a0132f3477fe34
- Source dataset
- uspto-grants-1978_04
- Patent number
- US04082850
Reaction notes
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