3-(Trifluoromethyl)benzoyl chloride → N'-(2-phenoxypyridine-3-carbonyl)-3-(trifluoromethyl)benzhydrazide

HRID 2084258

Reaction equation

HRID 2084258 reaction equation
[O:1]([C:8]1[N:17]=[CH:16][CH:15]=[CH:14][C:9]=1[C:10]([NH:12][NH2:13])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:18][C:19]([F:30])([F:29])[C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=1)[C:23](Cl)=[O:24]>N1C=CC=CC=1>[O:1]([C:8]1[C:9]([C:10]([NH:12][NH:13][C:23](=[O:24])[C:22]2[CH:26]=[CH:27][CH:28]=[C:20]([C:19]([F:18])([F:29])[F:30])[CH:21]=2)=[O:11])=[CH:14][CH:15]=[CH:16][N:17]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 752573-(Trifluoromethyl)benzoyl chlorideHCID 27976852-Phenoxynicotinohydrazide

Product 1

HCID 2797700N'-(2-phenoxypyridine-3-carbonyl)-3-(trifluoromethyl)benzhydrazide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Alternatively, as shown in scheme 2, reaction of 2-phenoxy-nicotinic acid hydrazide with 3-trifluoromethyl-benzoyl chloride in the presence of a base such as pyridine produced N′-(2-phenoxypyridine-3-carbonyl)-3-(trifluoromethyl)benzhydrazide as the product.

Sources & evidence

ORD record
ord-1bf87609dea646c894905922e97c9cf7
Source dataset
uspto-grants-2004_04
Patent number
US06716859B2

Linked notes

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