Ethyl 4-benzyloxy-1-(2-methylpropyl)indole-2-carboxylate → Ethyl 4-hydroxy-1-(2-methylpropyl)indole-2-carboxylate

HRID 2085126

Reaction equation

HRID 2085126 reaction equation
C([O:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[N:13]2[CH2:18][CH:19]([CH3:21])[CH3:20])C1C=CC=CC=1>[C].[Pd]>[OH:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[N:13]2[CH2:18][CH:19]([CH3:21])[CH3:20]

Participants

3

Reactant 1

HCID 22729270Ethyl 4-benzyloxy-1-(2-methylpropyl)indole-2-carboxylate

Product 1

HCID 22728995Ethyl 4-hydroxy-1-(2-methylpropyl)indole-2-carboxylate

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

By the reactions in the same manner as in Starting Material Synthesis Example 10 using ethyl 4-benzyloxy-1-(2-methylpropyl)indole-2-carboxylate (6.0 g) and 10% palladium-carbon (0.6 g), the title compound was obtained as pale-brown crystals.

Sources & evidence

ORD record
ord-2b62c205c414487fbb4321445e9c80b6
Source dataset
uspto-grants-2004_04
Patent number
US06720320B2

Linked notes

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