Chloroacetyl chloride → 4-chloro-N'-(2-chloroacetyl)benzohydrazide
Reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH2:9])=[O:7])=[CH:4][CH:3]=1.[Cl:12][CH2:13][C:14](Cl)=[O:15]>O1CCOCC1>[Cl:12][CH2:13][C:14]([NH:9][NH:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=1)=[O:15]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of p-chlorobenzoic hydrazide (11.2 g) in dioxane (100 ml) was added chIoroacetyl chloride (6 ml). The resulting mixture was refluxed for three hours, cooled to room temperature and filtered. The resulting solid was washed with ethyl ether and dried to yield N'-chloroacetyl-4-chlorobenzoic hydrazide as white solid.
Workup
- temperatureThe resulting mixture was refluxed for three hours
- filtrationfiltered
- washThe resulting solid was washed with ethyl ether
- customdried
Sources & evidence
- ORD record
- ord-20add643e25f4ff484bb9c80dc811185
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05728694
Reaction notes
Loading…