4'-Fluoroacetophenone → 4-Fluorophenylglyoxal hydrate

Reaction equation

O.[C:2]1([C:8]([CH:10]=[O:11])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:12]C1C=CC(C(=O)C)=CC=1>>[OH2:9].[F:12][C:5]1[CH:6]=[CH:7][C:2]([C:8]([CH:10]=[O:11])=[O:9])=[CH:3][CH:4]=1

Participants

Reactant 2

HCID 98284'-Fluoroacetophenone

HCID 12215922Glyoxal, phenyl-, hydrate

Product 1

HCID 27374704-Fluorophenylglyoxal hydrate

Procedure

The title compound was prepared using essentially the same procedure as described by H. A. Riley and A. R. Gray in Organic Synthesis, Collective Volume II, p. 509 for the preparation of phenylglyoxal hydrate, but using 4′-fluoroacetophenone in place of acetophenone.

Sources & evidence

ORD record: ord-518d1a45cbd74b60a796d8dc569cf6db
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06727244B2

Reaction notes

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