N-(2-iodophenyl)-2-methylpropanamide → Tert-butyl 4-[2-(isobutyrylamino)phenyl]-3,6-dihydro-1(2H)-pyridinecarboxylate

HRID 2087423

Reaction equation

HRID 2087423 reaction equation
I[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:13])[CH:10]([CH3:12])[CH3:11].CC1(C)C(C)(C)OB([C:22]2[CH2:23][CH2:24][N:25]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:26][CH:27]=2)O1>>[C:9]([NH:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[C:22]1[CH2:27][CH2:26][N:25]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:24][CH:23]=1)(=[O:13])[CH:10]([CH3:12])[CH3:11]

Participants

3

Reactant 2

HCID 3755027N-(2-iodophenyl)-2-methylpropanamideHCID 4642098Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate

Product 1

HCID 22049454Tert-butyl 4-[2-(isobutyrylamino)phenyl]-3,6-dihydro-1(2H)-pyridinecarboxylate

Procedure

Prepared by Procedure W and Scheme AF using N-(2-iodophenyl)-2-methylpropanamide and tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate: ESMS m/e: 245.1 (M−100)+.

Workup

  1. customPrepared by Procedure W and Scheme AF

Sources & evidence

ORD record
ord-34997a9aad4d435e8f5a982cdc3108c8
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Linked notes

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