4-Methylphenylhydrazine monohydrochloride → 2-Methyl-N-(3-{1-[3-(5-methyl-1H-indol-3-YL)propyl]-4-piperidinyl}phenyl)propanamide
Reaction equation
O1CCO[CH:2]1[CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][CH:13]([C:16]2[CH:17]=[C:18]([NH:22][C:23](=[O:27])[CH:24]([CH3:26])[CH3:25])[CH:19]=[CH:20][CH:21]=2)[CH2:12][CH2:11]1.Cl.[CH3:29][C:30]1[CH:35]=[CH:34][C:33]([NH:36]N)=[CH:32][CH:31]=1>>[CH3:26][CH:24]([CH3:25])[C:23]([NH:22][C:18]1[CH:19]=[CH:20][CH:21]=[C:16]([CH:13]2[CH2:14][CH2:15][N:10]([CH2:9][CH2:8][CH2:7][C:6]3[C:34]4[C:33](=[CH:32][CH:31]=[C:30]([CH3:29])[CH:35]=4)[NH:36][CH:2]=3)[CH2:11][CH2:12]2)[CH:17]=1)=[O:27]Participants
3
Procedure
Prepared by Procedure H and Scheme S using N-(3-{1-[4-(1,3-dioxolan-2-yl)butyl]-4-piperidinyl}phenyl)-2-methylpropanamide and 1-(4-methylphenyl)hydrazine hydrochloride: ESMS m/e: 418.2 (M+H)+.
Workup
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