Adipic Dihydrazide → Ceftiofur

HRID 2088288

Reaction equation

HRID 2088288 reaction equation
[CH3:1][O:2]/[N:3]=[C:4](\[C:11]([NH:13][C@@H:14]1[C:17](=[O:18])[N:16]2[C:19]([C:32]([OH:34])=[O:33])=[C:20]([CH2:23][S:24][C:25]([C:27]3[O:31][CH:30]=[CH:29][CH:28]=3)=[O:26])[CH2:21][S:22][C@H:15]12)=[O:12])/[C:5]1[N:9]=[C:8]([NH2:10])[S:7][CH:6]=1.Cl.C(NN)(=O)CCCCC(NN)=O>>[CH3:1][O:2]/[N:3]=[C:4](\[C:11]([NH:13][C@@H:14]1[C:17](=[O:18])[N:16]2[C:19]([C:32]([OH:34])=[O:33])=[C:20]([CH2:23][S:24][C:25]([C:27]3[O:31][CH:30]=[CH:29][CH:28]=3)=[O:26])[CH2:21][S:22][C@H:15]12)=[O:12])/[C:5]1[N:9]=[C:8]([NH2:10])[S:7][CH:6]=1

Participants

3

Reactant 2

HCID 66117Adipic DihydrazideHCID 9937686Ceftiofur Hydrochloride

Product 1

HCID 6328657Ceftiofur

Procedure

Ceftiofur-HCl (50 mg) and adipic acid dihydrazide (10 mg) were placed in a ml syringe. This syringe was connected to a second syringe containing 1 ml of oxidized dextran (Mw, 500,000; 85 mg/ml; 1 ml). The contents of the two syringes were mixed by making 20 reciprocations. A sample (200 μl) of the reaction mixture was transferred to a 2 ml centrifuge tube for the release experiment in PBS buffer. The release profile of the matrix appears in Table 4 below:

Workup

  1. customThis syringe was connected to a second syringe
  2. additionThe contents of the two syringes were mixed

Sources & evidence

ORD record
ord-570b2c73127d4c3d8e06511895f2400f
Source dataset
uspto-grants-2013_05
Patent number
US08435565B2

Linked notes

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