2',4'-Difluoro-biphenyl-4-sulfonyl chloride → HCID 178501245, compound

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([S:15](Cl)(=[O:17])=[O:16])=[CH:11][CH:10]=1.[NH2:19][C@H:20]1[CH2:25][CH2:24][C@H:23]([C:26]([O:28][CH3:29])=[O:27])[CH2:22][CH2:21]1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([S:15]([NH:19][C@H:20]2[CH2:21][CH2:22][C@H:23]([C:26]([O:28][CH3:29])=[O:27])[CH2:24][CH2:25]2)(=[O:17])=[O:16])=[CH:11][CH:10]=1

Participants

Reactant 2

HCID 448910942',4'-Difluoro-biphenyl-4-sulfonyl chloride

HCID 178501207HCID 178501207, compound

Product 1

HCID 178501245HCID 178501245, compound

Procedure

Using a method analogous to Method A with 2′,4′-difluorobiphenyl-4-sulfonyl chloride and methyl trans-4-aminocyclohexanecarboxylate, the title compound was obtained as a white solid.

Sources & evidence

ORD record: ord-73ed29ec2ec24b9595c7ff679d9aa96d
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08435968B2

Reaction notes

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