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Thiophene → Cyclohexanecarboxylic acid [2-(2-amino-5-benzoyl-benzylamino)-ethyl]-amide

HRID 2088772
Notes
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Reaction equation

HRID 2088772 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:6][C:3]=1[CH:4]=O.[NH2:18][CH2:19][CH2:20][NH:21][C:22]([CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1)=[O:23].S1C=CC=C1>CO.[Pd]>[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:6][C:3]=1[CH2:4][NH:18][CH2:19][CH2:20][NH:21][C:22]([CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1)=[O:23]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 3

HCID 8030ThiopheneHCID 13028009N-(2-aminoethyl)cyclohexanecarboxamideHCID 586251382-Amino-5-benzoylbenzaldehyde

Product 1

HCID 58625175Cyclohexanecarboxylic acid [2-(2-amino-5-benzoyl-benzylamino)-ethyl]-amide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalyst
HCID 887
Methanol
Solvent

Procedure

A mixture of 2-amino-5-benzoylbenzaldehyde (0.007 mol) and cyclohexanecarboxylic acid (2-amino-ethyl)-amide (0.007 mol) in methanol was hydrogenated at 50° C. with 10% Pd/C (0.5 g) as a catalyst in the presence of thiophene solution (1 mL). After uptake of H2 gas (1 equiv.) the catalyst was filtered off and the solvent evaporated. The residue was purified by column chromatography over silica gel (Biotage column) (eluent:CH2Cl2:methanol gradient). The desired fractions were collected and the solvent evaporated to yield the title compound as a residue.

Workup

  1. filtrationAfter uptake of H2 gas (1 equiv.) the catalyst was filtered off
  2. customthe solvent evaporated
  3. customThe residue was purified by column chromatography over silica gel (Biotage column) (eluent:CH2Cl2:methanol gradient)
  4. customThe desired fractions were collected
  5. customthe solvent evaporated

Sources & evidence

ORD record
ord-938dfaba28374d9d966eb3d6747ff952
Source dataset
uspto-grants-2013_05
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08436006B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes