2,2-Dimethylsuccinic anhydride → 4-[4-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-2,2-dimethyl-4-oxo-butyric acid

HRID 208911

Reaction equation

HRID 208911 reaction equation
[CH3:62][C:63]1([CH3:70])[C:64](=[O:65])[O:66][C:67](=[O:69])[CH2:68]1.[F:1][c:2]1[c:3]([F:4])[cH:5][c:6](-[c:7]2[cH:8][cH:9][c:10]([O:11][CH2:12][c:13]3[cH:14][cH:15][cH:16][c:17]4[c:18]3[cH:19][cH:20][n:21]4[C:22](=[O:23])[CH2:24][CH2:25][C:26]([OH:27])=[O:28])[cH:29][cH:30]2)[c:31]([O:32][CH3:33])[cH:34]1.[F:35][c:36]1[cH:37][c:38]([O:60][CH3:61])[c:39](-[c:43]2[cH:44][cH:45][c:46]([O:49][CH2:50][c:51]3[c:52]4[cH:53][cH:54][nH:55][c:56]4[cH:57][cH:58][cH:59]3)[cH:47][cH:48]2)[cH:40][c:41]1[F:42]>>[F:35][c:36]1[cH:37][c:38]([O:60][CH3:61])[c:39](-[c:43]2[cH:44][cH:45][c:46]([O:49][CH2:50][c:51]3[c:52]4[cH:53][cH:54][n:55]([C:67]([CH2:68][C:63]([CH3:62])([C:64](=[O:65])[OH:66])[CH3:70])=[O:69])[c:56]4[cH:57][cH:58][cH:59]3)[cH:47][cH:48]2)[cH:40][c:41]1[F:42]

Participants

4

Reactant 3

HCID 870672,2-Dimethylsuccinic anhydrideHCID 529397424-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-1H-indoleHCID 529397434-[4-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-4-oxo-butyric acid

Product 1

HCID 529397444-[4-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-2,2-dimethyl-4-oxo-butyric acid

Sources & evidence

ORD record
ord-c8bb5a6db2f74a8a97972279a115f762
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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