Glyoxylic Acid → (1-Methyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetic acid

Reaction equation

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([F:14])([F:13])[F:12])=[CH:8][CH:9]=2)[C:4]([NH2:15])=[N:3]1.[C:16]([OH:20])(=[O:19])[CH:17]=O>>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([F:12])([F:13])[F:14])=[CH:8][CH:9]=2)[C:4]([NH:15][CH2:17][C:16]([OH:20])=[O:19])=[N:3]1

Participants

Reactant 2

HCID 760Glyoxylic Acid

HCID 288753771-Methyl-5-(trifluoromethyl)-1H-indazol-3-amine

Product 1

HCID 67478753(1-Methyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetic acid

Procedure

The title compound was prepared as white solid from reductive amination of 1-methyl-5-trifluoromethyl-1H-indazol-3-ylamine (as prepared in the previous step) and glyoxylic acid using the procedure described in Step B of Example 1.

Sources & evidence

ORD record: ord-8293e9c914924dd5a2f77887b30b5deb
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08436023B2

Reaction notes

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