4-Chloro-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine → 2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinoline-7-carbonitrile

HRID 2090309Notes

Reaction equation

HRID 2090309 reaction equation
Cl[C:2]1[CH:7]=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[N:5]=[C:4]([NH2:15])[N:3]=1.[CH2:16]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([C:26]#[N:27])[CH:24]=2)[CH2:19][CH2:18][NH:17]1>>[NH2:15][C:4]1[N:3]=[C:2]([N:17]2[CH2:18][CH2:19][C:20]3[C:25](=[CH:24][C:23]([C:26]#[N:27])=[CH:22][CH:21]=3)[CH2:16]2)[CH:7]=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[N:5]=1

Participants

3

Reactant 2

HCID 14845194-Chloro-6-(4-methylpiperazin-1-yl)pyrimidin-2-amineHCID 101762437-Cyano-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 594022802-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinoline-7-carbonitrile

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 1 starting from 4-chloro-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine and 1,2,3,4-tetrahydroisoquinoline-7-carbonitrile (Asta Tech, Cat. No. 48330). LCMS (M+H)+: m/z=350.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-78604d54908c4b7296443f09674ebd41
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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