Thiophosgene → 5-Bromo-6-isothiocyanatoquinoxaline
Reaction equation
Br.[NH2:2][C:3]1[C:4]([Br:13])=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[N:6]2.[C:14](Cl)(Cl)=[S:15]>O>[Br:13][C:4]1[C:3]([N:2]=[C:14]=[S:15])=[CH:12][CH:11]=[C:10]2[C:5]=1[N:6]=[CH:7][CH:8]=[N:9]2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a stirred solution of 6-amino-5-bromoquinoxaline hydrobromide (10 g) in distilled water (150 ml) is added thiophosgene (3 ml). The solution is stirred for two hours at room temperature and the resultant precipitate is collected by filtration, washed with water, and dried to afford 5-bromo-6-isothiocyanato-quinoxaline.
Workup
- filtrationthe resultant precipitate is collected by filtration
- washwashed with water
- customdried
Sources & evidence
- ORD record
- ord-e9d07fddf886466f90f441150278fdb7
- Source dataset
- uspto-grants-2013_05
- Patent number
- US08440688B2
Reaction notes
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