4-Bromobenzyl bromide → 1-Bromo-4-((methylsulfonyl)methyl)benzene

HRID 2093485Notes

Reaction equation

HRID 2093485 reaction equation
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[CH3:10][S:11]([O:13][Na])=[O:12]>C(O)C>[CH3:10][S:11]([CH2:6][C:5]1[CH:8]=[CH:9][C:2]([Br:1])=[CH:3][CH:4]=1)(=[O:13])=[O:12]

Participants

4

Reactant 2

HCID 685274-Bromobenzyl bromideHCID 178504973HCID 178504973, compound

Product 1

HCID 27614151-Bromo-4-((methylsulfonyl)methyl)benzene

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

p-Bromobenzyl bromide (500 mg, 2 mmol) was refluxed with MeSO2Na (306 mg, 3 mmol) in Ethanol for 1 hour. The reaction was cooled, concentrated and purified by flash column (50% acetone/hexanes) to give the desired product.

Workup

  1. temperatureThe reaction was cooled
  2. concentrationconcentrated
  3. custompurified by flash column (50% acetone/hexanes)

Sources & evidence

ORD record
ord-eda08050a15f4ecd80044bec3b2dae57
Source dataset
uspto-grants-2013_05
Patent number
US08445499B2

Reaction notes

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