Sodium Ion → (RS)-1-(4-benzyloxy-phenyl)-3-bromo-pyrrolidin-2-one

Reaction equation

[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12]([NH:15][C:16]([CH:17]([CH2:18][CH2:19][Br:20])[Br:21])=[O:22])[cH:13][cH:14]1.[Cl:26][CH2:27][Cl:28].[Na+:24].[OH-:23].[OH2:25]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12]([N:15]2[C:16](=[O:22])[CH:17]([Br:21])[CH2:18][CH2:19]2)[cH:13][cH:14]1

Participants

Reactant 5

HCID 923Sodium Ion

HCID 961Hydroxide

HCID 962Water

HCID 6344Dichloromethane

HCID 23614762(RS)-N-(4-Benzyloxy-phenyl)-2,4-dibromo-butyramide

Product 1

HCID 23614761(RS)-1-(4-benzyloxy-phenyl)-3-bromo-pyrrolidin-2-one

Sources & evidence

ORD record: ord-9c434501a57d4ce79eaccd34709a008f
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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