Methyl triflate → ethyl 5-ethyl-2-(4-fluorophenyl)-1-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate
Reaction equation
[CH2:1]([C:3]1[NH:7][N:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[C:5](=[O:15])[C:4]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH3:2].F[C:22](F)(F)S(OC)(=O)=O>>[CH2:1]([C:3]1[N:7]([CH3:22])[N:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[C:5](=[O:15])[C:4]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH3:2]Participants
3
Procedure
In the same manner as in Reference Example 64 and using ethyl 5-ethyl-2-(4-fluorophenyl)-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate (3.1 g, 11 mmol) and methyl trifluoromethanesulfonate (3.7 mL) as starting materials, the title compound (1.9 g, 57%) was obtained as a pale-yellow solid.
Sources & evidence
- ORD record
- ord-a780dc1e55fd4b2c9623fa9b673c834e