2-Bromomethyl-6-(tetrahydrofuran-3-ylmethoxymethyl)pyridine → (RS)-3-{6-(Tetrahydrofuran-3-ylmethoxymethyl]pyridin-2-ylmethyl}-7-(5-methyl-2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamine

HRID 2096697

Reaction equation

HRID 2096697 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[C:8]3[NH:16][N:15]=[N:14][C:9]=3[N:10]=[C:11]([NH2:13])[N:12]=2)=[CH:4][CH:3]=1.Br[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25][O:26][CH2:27][CH:28]2[CH2:32][CH2:31][O:30][CH2:29]2)[N:20]=1>>[O:30]1[CH2:31][CH2:32][CH:28]([CH2:27][O:26][CH2:25][C:21]2[N:20]=[C:19]([CH2:18][N:14]3[C:9]4[N:10]=[C:11]([NH2:13])[N:12]=[C:7]([C:5]5[O:6][C:2]([CH3:1])=[CH:3][CH:4]=5)[C:8]=4[N:16]=[N:15]3)[CH:24]=[CH:23][CH:22]=2)[CH2:29]1

Participants

3

Reactant 2

HCID 667184092-Bromomethyl-6-(tetrahydrofuran-3-ylmethoxymethyl)pyridineHCID 178423995HCID 178423995, compound

Product 1

HCID 44555316(RS)-3-{6-(Tetrahydrofuran-3-ylmethoxymethyl]pyridin-2-ylmethyl}-7-(5-methyl-2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamine

Procedure

Prepared from 7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamine and 2-bromomethyl-6-(tetrahydrofuran-3-ylmethoxymethyl)pyridine by the alkylation method described for Example 36.

Sources & evidence

ORD record
ord-9832c3fff6ba4f3488e72d3305bd881e
Source dataset
uspto-grants-2013_05
Patent number
US08450328B2

Linked notes

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