1H-Indol-2-ylboronic acid → HCID 67190012, compound

HRID 2098690

Reaction equation

HRID 2098690 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)[C:5]2[S:10][C:9]([CH2:11][N:12]([CH3:20])[S:13]([CH2:16][CH2:17][CH2:18][Cl:19])(=[O:15])=[O:14])=[CH:8][C:6]=2[N:7]=1.[NH:27]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=[C:28]1B(O)O>>[NH:27]1[C:35]2[C:30](=[C:31]([C:2]3[N:3]=[C:4]([N:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)[C:5]4[S:10][C:9]([CH2:11][N:12]([CH3:20])[S:13]([CH2:16][CH2:17][CH2:18][Cl:19])(=[O:14])=[O:15])=[CH:8][C:6]=4[N:7]=3)[CH:32]=[CH:33][CH:34]=2)[CH:29]=[CH:28]1

Participants

3

Reactant 2

HCID 225673581H-Indol-2-ylboronic acidHCID 86618405HCID 86618405, compound

Product 1

HCID 67190012HCID 67190012, compound

Procedure

3-Chloro-propane-1-sulfonic acid (2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-methyl-amide was reacted with indole boronic acid in general procedure A. Purification on silica yielded 3-chloro-propane-1-sulfonic acid [2-(1H-indol-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl]-methyl-amide.

Workup

  1. customPurification on silica

Sources & evidence

ORD record
ord-163304ac6adf43458c2ce28580aeb606
Source dataset
uspto-grants-2013_05
Patent number
US08450315B2

Linked notes

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