HCID 23033740, compound → 3-(Hydroxymethyl)-1-methylpyrrolidin-2-one
Reaction equation
C([O:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH3:15])[C:11]1=[O:16])C1C=CC=CC=1>CO.[C].[Pd]>[OH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH3:15])[C:11]1=[O:16]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
3-[(Benzyloxy)methyl]-1-methylpyrrolidin-2-one (4.14 g, 18.88 mmol) was dissolved in methanol (20 ml), followed by addition of 10% hydrous palladium carbon (1.04 g) and the mixture was stirred at room temperature for 2 hours under hydrogen atmosphere. Palladium carbon was filtered off, and then the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/methanol: 10/1) to give the title compound (1.55 g, 64%) as a colorless oily matter.
Workup
- filtrationPalladium carbon was filtered off
- concentrationthe filtrate was concentrated under reduced pressure
- customThe residue was purified by silica gel column chromatography (eluent: ethyl acetate/methanol: 10/1)
Sources & evidence
- ORD record
- ord-04817e424a2740e2a926f577e4329c66
- Source dataset
- uspto-grants-2009_08
- Patent number
- US07569570B2
Reaction notes
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