3-Cyanophenol → HCID 178487666, compound

HRID 2100804Notes

Reaction equation

HRID 2100804 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6].Cl[C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:21][CH3:22])=[CH:18][CH:19]=2)[CH:14]=[C:13]([NH:23][C:24]2[CH:28]=[CH:27][NH:26][N:25]=2)[N:12]=1>>[CH3:22][O:21][C:17]1[CH:16]=[C:15]2[C:20](=[CH:19][CH:18]=1)[C:11]([O:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6])=[N:12][C:13]([NH:23][C:24]1[CH:28]=[CH:27][NH:26][N:25]=1)=[CH:14]2

Participants

3

Reactant 2

HCID 133943-CyanophenolHCID 178487533HCID 178487533, compound

Product 1

HCID 178487666HCID 178487666, compound

Procedure

Similar procedure as described in example 10 was used, starting from 3-hydroxy-benzonitrile and (1-chloro-6-methoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine to give 3-[6-methoxy-3-(1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-benzonitrile. LC-MS m/e 358(MH+).

Sources & evidence

ORD record
ord-14974739d5b846f2ae3227237d82dd81
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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