Diethylene Glycol Monoethyl Ether → HCID 178468022, compound

Reaction equation

Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1.[CH2:18]([O:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][OH:26])[CH3:19]>>[CH2:18]([O:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][O:26][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1)[CH3:19]

Participants

Reactant 2

HCID 8146Diethylene Glycol Monoethyl Ether

HCID 178478391HCID 178478391, compound

Product 1

HCID 178468022HCID 178468022, compound

Procedure

Similar procedure as described in example 10 was used, starting from (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 2-(2-ethoxy-ethoxy)-ethanol to give {1-[2-(2-ethoxy-ethoxy)-ethoxy]-isoquinolin-3-yl}-(1H-pyrazol-3-yl)-amine. LC-MS m/e 343(MH+).

Sources & evidence

ORD record: ord-302ccded5c4f422787f14855c413597d
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07572809B2

Reaction notes

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