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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2102134Generated: October 27, 2026

3-(Trifluoromethyl)phenylboronic acid → 2-Methyl-4-(trifluoromethyl)-1-({2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/2102134

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)phenylboronic acidHCID 2734388—
Reactant1-[(2-Bromo-1,3-thiazol-4-yl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67404358—
Product2-Methyl-4-(trifluoromethyl)-1-({2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methyl)-1H-indole-5-carbonitrileHCID 86620697—

Reaction Steps

Synthesized as described in Example 310D using 1-[(2-bromo-1,3-thiazol-4-yl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 311B) and [3-(trifluoromethyl)phenyl]boronic acid: MS (ES) m/z 466 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07572820B2
Source datasetuspto-grants-2009_08
ORD IDord-ccffb75e95ef4ec1aa4a8c91592cf4c6
Source noteuspto-grants-2009_08