5-Chloro-3-(chloromethyl)-1,2,4-thiadiazole → 1-[(5-Chloro-1,2,4-thiadiazol-3-yl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

HRID 2102156

Reaction equation

HRID 2102156 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([C:11]([F:14])([F:13])[F:12])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=2.[Cl:17][C:18]1[S:22][N:21]=[C:20]([CH2:23]Cl)[N:19]=1>>[Cl:17][C:18]1[S:22][N:21]=[C:20]([CH2:23][N:3]2[C:4]3[C:9](=[C:8]([C:11]([F:12])([F:14])[F:13])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=3)[CH:10]=[C:2]2[CH3:1])[N:19]=1

Participants

3

Reactant 2

HCID 3326105-Chloro-3-(chloromethyl)-1,2,4-thiadiazoleHCID 533093462-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 674050131-[(5-Chloro-1,2,4-thiadiazol-3-yl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Procedure

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 5-chloro-3-(chloromethyl)-1,2,4-thiadiazole: MS (ES) m/z 357 (M+1) and 359 (M+1, isotope).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-de253b7a491044268b4449716a19d619
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Linked notes

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