4-Piperidinamine → 4,8-bis-(2-chloro-phenyl)-2-(piperidin-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

Reaction equation

[Cl:1][c:2]1[c:3](-[c:8]2[c:9]3[c:10]([n:11][c:12]([S:14]([CH3:15])(=[O:16])=[O:17])[n:13]2)[n:18](-[c:23]2[c:24]([Cl:29])[cH:25][cH:26][cH:27][cH:28]2)[c:19](=[O:22])[cH:20][cH:21]3)[cH:4][cH:5][cH:6][cH:7]1.[NH:30]1[CH2:31][CH2:32][CH:33]([NH2:36])[CH2:34][CH2:35]1>>[Cl:1][c:2]1[c:3](-[c:8]2[c:9]3[c:10]([n:11][c:12]([NH:36][CH:33]4[CH2:32][CH2:31][NH:30][CH2:35][CH2:34]4)[n:13]2)[n:18](-[c:23]2[c:24]([Cl:29])[cH:25][cH:26][cH:27][cH:28]2)[c:19](=[O:22])[cH:20][cH:21]3)[cH:4][cH:5][cH:6][cH:7]1

Participants

Reactant 2

HCID 4243614-Piperidinamine

HCID 102255784,8-bis-(2-chloro-phenyl)-2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one

Product 1

HCID 596395514,8-bis-(2-chloro-phenyl)-2-(piperidin-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

Sources & evidence

ORD record: ord-ff2cfcc46dc745c1a58de1f299070152
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…