4-Pyridineethanamine → 4-Chloro-7-(1-(tert-butoxycarbonyl)-5-[(2-(pyridin-4-yl)ethyl)aminomethyl]indol-2-yl)isoindolinone

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Reaction Steps

In a similar manner to Step 1 of Example 56, 4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (20.0 mg, 0.0487 mmol) was dissolved in dichloromethane (0.5 mL). The solution was treated with 4-(2-aminoethyl)pyridine (0.012 mL, 0.10 mmol) and sodium triacetoxyborohydride (32 mg, 0.15 mmol) to obtain 4-chloro-7-(1-(tert-butoxycarbonyl)-5-[(2-(pyridin-4-yl)ethyl)aminomethyl]indol-2-yl)isoindolinone.

Provenance & Evidence