Tolylboronic acid → [4-(4-Methylphenyl)-8-(Trifluoromethyl)Quinolin-3-yl](Pyridin-2-yl)Methanone

HRID 2104477

Reaction equation

HRID 2104477 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)=[O:17].[CH3:24][C:25]1[CH:30]=[CH:29][C:28](B(O)O)=[CH:27][CH:26]=1>>[CH3:24][C:25]1[CH:30]=[CH:29][C:28]([C:2]2[C:11]3[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=3)[N:5]=[CH:4][C:3]=2[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=2)=[O:17])=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 79799Tolylboronic acidHCID 66913162(4-Chloro-8-trifluoromethyl-quinolin-3-yl)-pyridin-2-yl-methanone

Product 1

HCID 11429278[4-(4-Methylphenyl)-8-(Trifluoromethyl)Quinolin-3-yl](Pyridin-2-yl)Methanone

Procedure

This compound was prepared using the procedure of Example 1, step 5 using (4-chloro-8-trifluoromethyl-quinolin-3-yl)-pyridin-2-yl-methanone in place of [4-chloro-8-(trifluoromethyl)quinolin-3-yl](phenyl)methanone and 4-methylphenylboronic acid in place of phenyl boronic acid. MS (ESI) m/z 393 ([M+H]+); Anal. Calcd for C23H15F3N2O.0.2H2O: C, 69.76; H, 3.92; N, 7.07. Found: C, 69.73; H, 3.79; N, 6.99.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-66e517bce71d40599a1576d414f449ae
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Linked notes

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