1,1'-Biphenyl-4-yl-boronic acid → [4-(1,1'-Biphenyl-4-yl)-8-(Trifluoromethyl)Quinolin-3-yl](Pyridin-2-yl)Methanone

HRID 2104478

Reaction equation

HRID 2104478 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)=[O:17].[C:24]1([C:30]2[CH:35]=[CH:34][C:33](B(O)O)=[CH:32][CH:31]=2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[C:24]1([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:29]=[CH:28][C:27]([C:2]2[C:11]3[C:6](=[C:7]([C:12]([F:14])([F:15])[F:13])[CH:8]=[CH:9][CH:10]=3)[N:5]=[CH:4][C:3]=2[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=2)=[O:17])=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 1512531,1'-Biphenyl-4-yl-boronic acidHCID 66913162(4-Chloro-8-trifluoromethyl-quinolin-3-yl)-pyridin-2-yl-methanone

Product 1

HCID 11396865[4-(1,1'-Biphenyl-4-yl)-8-(Trifluoromethyl)Quinolin-3-yl](Pyridin-2-yl)Methanone

Procedure

This compound was prepared using the procedure of Example 1, step 5 using (4-chloro-8-trifluoromethyl-quinolin-3-yl)-pyridin-2-yl-methanone in place of [4-chloro-8-(trifluoromethyl)quinolin-3-yl](phenyl)methanone and 4-(phenyl)phenylboronic acid in place of phenyl boronic acid. MS (ESI) m/z 455 ([M+H]+); Anal. Calcd for C28H17F3N2O: C, 74.00; H, 3.77; N, 6.16. Found: C, 73.99; H, 3.81; N, 5.92.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-06866ebc32124b64894cf40fa1cf27c8
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Linked notes

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