4-Chlorophenylboronic acid → [4-(4-Chlorophenyl)-8-(Trifluoromethyl)Quinolin-3-yl](Pyridin-2-yl)Methanone

HRID 2104480

Reaction equation

HRID 2104480 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)=[O:17].[Cl:24][C:25]1[CH:30]=[CH:29][C:28](B(O)O)=[CH:27][CH:26]=1>>[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([C:2]2[C:11]3[C:6](=[C:7]([C:12]([F:14])([F:13])[F:15])[CH:8]=[CH:9][CH:10]=3)[N:5]=[CH:4][C:3]=2[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=2)=[O:17])=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 66913162(4-Chloro-8-trifluoromethyl-quinolin-3-yl)-pyridin-2-yl-methanone

Product 1

HCID 11200776[4-(4-Chlorophenyl)-8-(Trifluoromethyl)Quinolin-3-yl](Pyridin-2-yl)Methanone

Procedure

This compound was prepared using the procedure of Example 1, step 5 using (4-chloro-8-trifluoromethyl-quinolin-3-yl)-pyridin-2-yl-methanone in place of [4-chloro-8-(trifluoromethyl)quinolin-3-yl](phenyl)methanone and 4-chlorophenylboronic acid in place of phenyl boronic acid; MS (ESI) m/z 413/415 ([M+H]+); Anal. Calcd for C22H12ClF3N2O: C, 64.01; H, 2.93; N, 6.79. Found: C, 63.66; H, 3.03; N, 6.60.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-1099040f4d0c41728bed29ac630df64f
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Linked notes

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