Methyl 3-(3-hydroxyphenyl)propionate → 3-[3-({3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Benzyl}Oxy)Phenyl]Propanoic Acid

HRID 2104567

Reaction equation

HRID 2104567 reaction equation
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([CH2:24][OH:25])[CH:21]=[CH:22][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:26]([F:29])([F:28])[F:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O:31][C:32](=[O:42])[CH2:33][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[C:37](O)[CH:36]=1>>[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([CH:21]=[CH:22][CH:23]=1)[CH2:24][O:25][C:39]1[CH:40]=[C:35]([CH2:34][CH2:33][C:32]([OH:42])=[O:31])[CH:36]=[CH:37][CH:38]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:26]([F:29])([F:27])[F:28])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 1512675Methyl 3-(3-hydroxyphenyl)propionateHCID 11223110{3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}Methanol

Product 1

HCID 669136163-[3-({3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Benzyl}Oxy)Phenyl]Propanoic Acid

Procedure

The title compound was prepared from [3-(3-benzyl-8-trifluoromethyl-quinolin-4-yl)-phenyl]-methanol and 3-(3-hydroxy-phenyl)-propionic acid methyl ester according to the procedure of Example 69. MS (ESI) m/z 542.

Sources & evidence

ORD record
ord-874f45eb13694a2d97d7e534db2a30b5
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Linked notes

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