{3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}Methanol → 3-[4-({3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Benzyl}Oxy)Phenyl]PROP-2-Ynoic Acid

HRID 2104569

Reaction equation

HRID 2104569 reaction equation
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([CH2:24][OH:25])[CH:21]=[CH:22][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:26]([F:29])([F:28])[F:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O:31][C:32](=[O:43])[C:33]#[C:34][C:35]1[CH:40]=[CH:39][C:38](CO)=[CH:37][CH:36]=1>>[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([CH:21]=[CH:22][CH:23]=1)[CH2:24][O:25][C:38]1[CH:39]=[CH:40][C:35]([C:34]#[C:33][C:32]([OH:43])=[O:31])=[CH:36][CH:37]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:26]([F:29])([F:27])[F:28])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 11223110{3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}MethanolHCID 66913683(4-Hydroxymethyl-phenyl)-propynoic acid methyl ester

Product 1

HCID 669136433-[4-({3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Benzyl}Oxy)Phenyl]PROP-2-Ynoic Acid

Procedure

The title compound was prepared from [3-(3-benzyl-8-trifluoromethyl-quinolin-4-yl)-phenyl]-methanol and (4-hydroxymethyl-phenyl)-propynoic acid methyl ester according to the procedure of Example 69. MS (ESI) m/z 538.

Sources & evidence

ORD record
ord-e7e60275d9084440a95ed3c28711842c
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Linked notes

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