(1,2-Oxazol-5-yl)methanethiol → 4-[[(1R)-2-Hydroxy-1-methylethyl]amino]-2-[(5-isoxazolylmethyl)thio]-7(8H)-pteridinone
Reaction equation
F[C:2]1[C:7](F)=CC=C[C:3]=1[CH2:9][S:10]([C:13]1[N:22]=[C:21]([NH:23][C@H:24]([CH3:27])[CH2:25][OH:26])[C:20]2[N:19]=[CH:18][C:17](=[O:28])[NH:16][C:15]=2[N:14]=1)(=O)=O.[O:29]1C(CS)=CC=[N:30]1>>[OH:26][CH2:25][C@H:24]([NH:23][C:21]1[C:20]2[N:19]=[CH:18][C:17](=[O:28])[NH:16][C:15]=2[N:14]=[C:13]([S:10][CH2:9][C:3]2[O:29][N:30]=[CH:7][CH:2]=2)[N:22]=1)[CH3:27]Participants
3
Procedure
The titled compound (0.038 g) was prepared by the method of Example 13, step (c) using the product from Example 13, step (a) (00.10 g) and 5-isoxazolylmethylmercaptan (0.057 g).
Sources & evidence
- ORD record
- ord-e03ddded21954095a204da056b78c2ab
- Source dataset
- uspto-grants-2009_08